Clinical Versus Research Sequencing

Exome Sequencing – Research and Clinical Applications

Litigation in clinical research: malpractice doctrines versus research realities.

uman clinical research trials, by which corporations, universities, and research scientists bring new drugs, devices, H and procedures into the practice and marketplace of medicine, have become a huge business. The National Institutes of Health (NIH) doubled its spending over the past five years,’ while in the private sector the top twenty pharmaceutical companies have more than doubled their i...

Basic research and clinical application of immune repertoire sequencing

The adaptive immune system uses several strategies to generate a repertoire of Tand B-cell antigen receptors (TCR/BCR) with sufficient diversity to recognize the wide array of potential pathogens. The Immunoglobulin and TCR repertoires are a mirror of the human immune system, which reflects processes caused by infections, cancer, autoimmunity and aging. The rapid advances in sequencing technolo...

Translating exome sequencing from research to clinical diagnostics.

In the relatively short time frame since the introduction of next generation sequencing, it has become a method of choice for complex genomic research studies. As a paradigm shifting technology, we are now witnessing its translation into clinical diagnostic laboratories for patient care. Multi-gene panels for a variety of disorders are now available in several clinical laboratories based on tar...

Genome Sequencing Practices and the Future of Clinical Research

Genome sequencing is one of the latest technologies to be introduced for use in clinical trials. It is often used in the practice of genomic medicine, with the objective of processing information about genes and markers to treat disease. Specifically, genomic medicine uses DNA and RNA platform sequencing technologies to analyze the human genome to detect diseases caused by gene mutations. In 20...